Emergency services were called to Cobb Hall Road in Newton Longville at around 9.44am on Sunday following reports of an explosion at a home.
Buckinghamshire Fire & Rescue Service initially described the incident as a suspected gas explosion within a domestic property.
Four fire engines, a command unit, an operational support unit and two officers were sent to the scene.
One man was injured and passed into the care of South Central Ambulance Service. Thames Valley Police has since confirmed that he required hospital treatment and remains in hospital.
Firefighters used a main jet and a hose reel jet as they dealt with the incident, working alongside police and ambulance crews.
Cordons were put in place around the scene, with emergency services asking people to avoid the immediate area while their work continued.
In its latest update, Thames Valley Police said officers remained at the scene supporting Buckinghamshire Fire & Rescue Service and other emergency service partners.
The exact cause of the explosion has not yet been confirmed.
The MP for Buckingham and Bletchley has praised residents and emergency services following the suspected gas explosion which destroyed a bungalow in Newton Longville on Sunday morning.
Callum Anderson MP has been speaking following the incident on Cobb Hall Road, which left one resident seriously injured and led to more than 30 nearby homes being evacuated while emergency services worked to make the area safe.
Mr Anderson said his thoughts were with the injured resident, who remains in hospital, as well as his family, friends, neighbours and those displaced by the incident.
He also praised the response of the Newton Longville community, describing the way local people came together as "extraordinary".
Particular thanks were given to Newton Longville Parish Council, Buckinghamshire Council, The Crooked Billet and residents who stepped forward to help those affected.
Mr Anderson said he had been particularly moved by reports of neighbours rushing to help before emergency services arrived.
The Parish Council supported affected residents, while Buckinghamshire Council helped arrange emergency accommodation. The Crooked Billet also opened its doors to provide a hub for people affected by the incident.
Following a visit to Longueville Hall on Monday afternoon, Mr Anderson said it was clear how "caring, resilient and close-knit" the village is.
He also thanked the emergency services for what he described as their swift and professional response.
The MP has now met with gas distribution company SGN and says he has been assured he will be kept informed of developments as investigations continue into how the incident happened.

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