Train operator Chiltern Railways has warned customers that no services will operate on Wednesday 1 and Friday 3 February on any route due to strike action by ASLEF and the RMT.
The strike action is expected to similarly impact other neighbouring train operators, and as such, all Chiltern stations will be closed.
There will be a handful of minor amendments and cancellations to late-night services on Thursday 2 February due to the strike action.
Customers are also warned that due to Network Rail engineering works, London Marylebone station will be closed on Saturday 4 and Sunday 5 February.
An amended timetable will be in operation, with all Chiltern Railways services commencing and terminating at West Ruislip throughout the weekend, allowing for a connection to/from Central London on the London Underground.
Owing to further engineering works, there will be no trains between Amersham and Aylesbury Vale Parkway, with a replacement bus in operation beginning at West Ruislip and serving stations between Amersham and Aylesbury Vale Parkway.
If customers are intending to travel on days affected by engineering works, they are urged to plan ahead and triple check their journey on the Chiltern Railways website or app.